姓名：付书林
性别：男
职称：副教授
最高学历、学位：博士
毕业院校：华中农业大学
从事专业：预防兽医学
E-Mail：fushulin2016@126.com
个人简介
付书林，博士，副教授，硕士研究生导师，常青学者，湖北省科技副总，湖北省科技特派员。2007年6月，毕业于华中农业大学动物医学院动物医学专业，获农学学士学位；2013年6月，毕业于华中农业大学动物科学动物医学院预防兽医学专业，获农学博士学位。主要从事猪细菌性疾病细菌分子致病机制、免疫机理及新型抗生素替代品研发。迄今主持或参与国家自然科学基金、国家重点研发计划、湖北省自然科学基金、湖北省教育厅科技计划项目等十余项；在领域重要国内外学术期刊发表学术论文三十余篇。
教育经历
2007/09－2013/06，华中农业大学，动物科学与动物医学院，预防兽医学专业，硕博连读，博士；
2003/09－2007/06，华中农业大学，动物科学与动物医学院，动物医学专业，学士。
研究工作经历
2015/12-至今，武汉轻工大学
A.猪细菌性疾病细菌分子免疫致病机制
B.新型抗生素替代品研发
研究方向
1.猪细菌性疾病细菌分子免疫致病机制；
2.新型抗生素替代品研发
主持及参与科研项目
1、基于PD-1/PD-L1轴为靶点的黄芩苷抗副猪嗜血杆菌病免疫抑制的机制研究，国家自然科学基金面上项目，32273067，54万元，主持。
2、双组分信号转导系统CpxA/CpxR调控副猪嗜血杆菌致病性的分子机制研究，国家自然科学基金青年基金项目，31402225，25万元，主持。
3、fis基因在副猪嗜血杆菌致病过程中作用机制研究，湖北省教育厅重点项目，D20201607，4万元，主持。
4、副猪嗜血杆菌诱导细胞焦亡的机理研究，湖北省科技厅面上项目，2017CFB446，3万元，主持。
5一种副猪嗜血杆菌快速检测方法的建立及应用，武汉巴菲尔生物技术服务有限公司，whpu-2019-cg-034，9万元，主持。
6一种猪链球菌快速检测方法的建立及应用，武汉巴菲尔生物技术服务有限公司，whpu-2019-cg-079，6万元，主持。
主持教研项目
1. 2016年校级教学研究项目，《动物预防医学》课程学习评价方式改革试点项目，主持
2. 2022年校级揭榜制教学研究项目，具有行业特色背景的地方高校课程思政建设研究，主持
发表论文（*通讯作者）
1. Fu S, Yuan Y, Tian X, Zhou L, Guo L, Zhang D, He J, Peng C, Qiu Y, Ye C, Liu Y, Zong B. Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations. Vet Sci. 2022;9(12):666.
2. Peng L, Peng C,Fu S, Qiu Y.Adsorption-desorption and degradation of colistin in soils under aerobic conditions.Ecotoxicol Environ Saf. 2022;243:113989.
3. Lu Q, Zhou L, Wang Z, Li X, Ding L, Qiu Y, Guo P, Ye C,Fu S, Wu Z, Liu Y.Baicalin Alleviate Apoptosis via PKC-MAPK Pathway in Porcine Peritoneal Mesothelial Cells Induced byGlaesserella parasuis.Molecules. 2022;27(16):5083.
4.Guo L, Cheng H,Fu S, Liu J, Zhang Y, Qiu Y, Chen H.Methylome and Transcriptome-Based Integration Analysis Identified Molecular Signatures Associated With Meningitis Induced byGlaesserella parasuis.Front Immunol. 2022;13:840399.
5．Guo L, Zhang D,Fu S, Zhang J, Zhang X, He J, Peng C, Zhang Y, Qiu Y, Ye C, Liu Y, Wu Z, Hu CA. Metagenomic Sequencing Analysis of the Effects of Colistin Sulfate on the Pig Gut Microbiome. Front Vet Sci. 2021;8:663820.
6．Guo L, He J, Zhang J, Zhang X, Zhang D, Zhou L, Yuan Y,Fu S, Qiu Y, Ye C, Liu Y, Wu Z, Hu CA. Baicalin-Aluminum Modulates the Broiler Gut Microbiome. DNA Cell Biol. 2021;40(7):881-894.
7．Liu Y, Li X, Zhang Z, Zhang J, Xu J, Qiu Y, Ye C,Fu S, Wu Z, Hu CA. Baicalin Protects Vascular Tight Junctions in Piglets During Glaesserella parasuis Infection. Front Vet Sci. 2021;8:671936.
8．Fu S, Meng Q, Zhang D, Zuo S, He J, Guo L, Qiu Y, Ye C, Liu Y, Hu CA. Effect of Baicalin on Transcriptome Changes in Piglet Vascular Endothelial Cells Induced by a Combination of Glaesserella parasuis and Lipopolysaccharide. DNA Cell Biol. 2021;40(6):776-790.
9．Peng C, Zuo S, Qiu Y,Fu S, Peng L. Determination of Colistin in Contents Derived from Gastrointestinal Tract of Feeding Treated Piglet and Broiler.Antibiotics (Basel). 2021;10(4):422.
10．Zhang J, Zhang Z, Xu J, Ye C,Fu S, Hu CA, Qiu Y, Liu Y. Protective Effects of Baicalin on Peritoneal Tight Junctions in Piglets Challenged with Glaesserella parasuis.Molecules. 2021;26(5):1268.
11．Fu S, Liu J, Xu J, Zuo S, Zhang Y, Guo L, Qiu Y, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis. Mol Cell Biochem. 2020;472(1-2):45-56.
12．Fu S, Yin R, Zuo S, Liu J, Zhang Y, Guo L, Qiu Y, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. The effects of baicalin on piglets challenged with Glaesserella parasuis.Vet Res. 2020;51(1):102.
13．Guo L, Liu J, Zhang Y,Fu S, Qiu Y, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. The Effect of Baicalin on the Expression Profiles of Long Non-Coding RNAs and mRNAs in Porcine Aortic Vascular Endothelial Cells Infected with Haemophilus parasuis.DNA Cell Biol. 2020;39(5):801-815.
14．Guo L, Li L, Zhang Y,Fu S, Zhang J, Wang X, Zhu H, Qiao M, Wu L, Liu Y. Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis.Innate Immun. 2019;25(8):491-502.
15．Fu S, Zhao W, Xiong C, Guo L, Guo J, Qiu Y, Hu CA, Ye C, Liu Y, Wu Z, Hou Y. Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion. Innate Immun. 2019;25(7):420-432.
16．Liu Y, Zhao W, Xu J, Yu X, Ye C,Fu S, Qiu Y. Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets.J Vet Pharmacol Ther. 2019;42(5):580-584.
17．Fu S, Zhuang F, Guo L, Qiu Y, Xiong J, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets. Int J Mol Sci. 2019;20(10):2390.
18．Ye C, Li R, Xu L, Qiu Y,Fu S, Liu Y, Wu Z, Hou Y, Hu CA. Effects of Baicalin on piglet monocytes involving PKC-MAPK signaling pathways induced by Haemophilus parasuis.BMC Vet Res. 2019;15(1):98.
19．Guo L, Guo J, Liu H, Zhang J, Chen X, Qiu Y,Fu S*. Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis. J Vet Med Sci. 2018;80(7):1047-1053.
20．Fu S, Guo J, Li R, Qiu Y, Ye C, Liu Y, Wu Z, Guo L, Hou Y, Hu CA. Transcriptional Profiling of Host Cell Responses to Virulent Haemophilus parasuis: New Insights into Pathogenesis.Int J Mol Sci. 2018;19(5):1320.
21．Fu S, Liu H, Chen X, Qiu Y, Ye C, Liu Y, Wu Z, Guo L, Hou Y, Hu CA. Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation. Int J Mol Sci. 2018;19(5):1307.
22．Fu S, Liu H, Xu L, Qiu Y, Liu Y, Wu Z, Ye C, Hou Y, Hu CA. Baicalin modulates NF-κB and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glässer's disease.Sci Rep. 2018;8(1):807.
23．Yang B, Lei Z, Zhao Y, Ahmed S, Wang C, Zhang S,Fu S, Cao J, Qiu Y. Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation. Front Microbiol. 2017;8:2125.
24．Lei Z,Fu S, Yang B, Liu Q, Ahmed S, Xu L, Xiong J, Cao J, Qiu Y. Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis. Sci Rep. 2017;7(1):7517.
25．Guo L, Xu L, Wu T,Fu S*, Qiu Y, Hu CA, Ren X, Liu R, Ye M. Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model.Can J Microbiol. 2017;63(4):312-320.
26．Fu S, Xu L, Li S, Qiu Y, Liu Y, Wu Z, Ye C, Hou Y, Hu CA.Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection. Vet Res. 2016;47(1):80.
27．Chen J, Li W, Jin E, He Q, Yan W, Yang H, Gong S, Guo Y,Fu S, Chen X, Ye S, Qian Y. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.Res Vet Sci. 2016;106:159-64.
28．Yao Y,Fu S, He B, Chen X, Shao Z, Yang W, Chen J. Complete Genome Sequences of an H5N1 Highly Pathogenic Avian Influenza Virus Isolated from Pigeon in China in 2012. Genome Announc.2015;3(6):e01330-15.
29．Zhang J,Fu SL, Liu Y, Liu YL, Wang WJ.Analysis of MicroRNA Expression Profiles in Weaned Pig Skeletal Muscle after Lipopolysaccharide Challenge.Int J Mol Sci. 2015;16(9):22438-55.
30．Liu J, Hu L, Xu Z, Tan C, Yuan F,Fu S, Cheng H, Chen H, Bei W. Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence.Vet Microbiol. 2015;177(1-2):184-92.
31．Xu J,Fu S, Liu M, Xu Q, Bei W, Chen H, Tan C. The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2.Microbiol Res. 2014;169(7-8):541-6.
32．Fu S, Ou J, Zhang M, Xu J, Liu H, Liu J, Yuan F, Chen H, Bei W. The live attenuated Actinobacillus pleuropneumoniae triple-deletion mutant ΔapxIC ΔapxIIC ΔapxIV-ORF1 strain, SLW05, Immunizes pigs against lethal challenge with Haemophilus parasuis. Clin Vaccine Immunol. 2013;20(2):134-9.
33．Fu S, Zhang M, Xu J, Ou J, Wang Y, Liu H, Liu J, Chen H, Bei W. Immunogenicity and protective efficacy of recombinant Haemophilus parasuis SH0165 putative outer membrane proteins.Vaccine. 2013;31(2):347-53.
34．Fu S, Zhang M, Ou J, Liu H, Tan C, Liu J, Chen H, Bei W. Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice.Vaccine. 2012;30(48):6839-44.
35．Fu S, Yuan F, Zhang M, Tan C, Chen H, Bei W. Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate dehydrogenase, of Haemophilus parasuis. Res Vet Sci. 2012;93(1):57-62.
