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邱银生

时间:2021-03-03    作者:     浏览次数:

研究领域:抗生素替代品研发、饲料中有害物质检测与控制、动物排泄物中抗生素对环境的影响。

学习经历

1985年7月毕业于华中农业大学动物医学专业,获学士学位;

1988年7月毕业于东北农业大学兽医药理学与毒理学专业,获硕士学位;

2003年6月毕业于华中农业大学农产品加工与贮藏工程专业,获博士学位。

工作经历

1988年10月进入湖北省医药工业研究院药理毒理实验中心工作,曾任药理毒理实验中心主任和湖北省药物安全性评价中心主任。2006年5月调入武汉轻工大学任教,现任英国上市公司官网365院长、教授。

兼职情况

现兼任中国兽药典第六届委员会委员、农业部第七届兽药审评委员会委员、中国畜牧兽医学会兽医药理毒理学分会副理事长、武汉市畜牧兽医学会副理事长、湖北省药理学会理事、武汉药理学会常务理事。

主要业绩

组织完成了湖北省科技厅的重点项目“湖北省药物安全性评价中心建设”项目,并通过了国家食品药品监督管理局的GLP认证检查。主持完成了国家二类兽药盐酸沙拉沙星原料药及制剂的研究工作,获得了国家新兽药证书4个。与企业合作获得了“马波沙星原料药和片剂”、“阿莫西林硫酸粘菌素可溶性粉”的国家新兽药证书。

近年承担的科研项目

1.主持国家自然基金面上项目:基于Panx-1/P2X7与P2Y6靶点的黄芩苷抗副猪嗜血杆菌病血管内皮屏障损伤的研究(32072917),2021-2024。

2.主持国家重点研发计划子课题:畜禽药物的代谢转归和耐药性形成机制研究(2018YFD0500301),2018-2020。

3.主持国家重点研发计划子课题:病原菌耐药性消减技术研究(2016YFD05011307),2016-2020。

4.主持国家自然基金面上项目:NLRP3/caspase-1和HMGB1/RAGE在副猪嗜血杆菌病炎症中的作用及黄芩苷的干预效果(31572572),2016-2019。

5.主持国家自然基金面上项目:对乙酰胺基酚联合乙酰半胱氨酸对仔猪免疫应激性炎症的协同抑制作用及其调控机制(30972213),2010-2012。

6.主持湖北省自然科学基金重点项目:猪抗病营养及其分子调控机理的研究(2008CDA081),2009-2013。

获奖情况

获得湖北省科技进步奖6项,其中“家禽消化道生理机能的调控技术研究与产品开发” 2012年获湖北省科技进步二等奖(第4人),“仔猪生理机能营养调控与饲料产业化关键技术” 2011年获湖北省科技进步一等奖(第6人),“盐酸阿扑吗啡舌下片”的研制2009年获湖北省科技进步二等奖(第4人),“龙胆泻肝胶囊”的研制2005年获湖北省科技进步三等奖(第2人),“盐酸西替立嗪原料及制剂”的研制2004年获湖北省科技进步二等奖(第3人),“兽用抗菌新药-烟酸诺氟沙星”的研制1997年获湖北省科技进步三等奖(第3人)。

专著与发表论文

专著

1.胡功政,邱银生主编.家禽常用药物及其合理使用.郑州::河南科技出版社,2010年

2.副主译,兽医药理学与治疗学(Jim Riviere and Mark G. Papich.主编,第九版).北京:中国农业出版社,2012

3.参编.饲料药物学,北京:中国农业出版社,2001

4.参编.兽药使用指南.北京:中国农业出版社,2005版和2010版

5.参编.纳米药物.北京:清华大学出版社,2007

发表论文

1.Qirong Lu, Wantong Han, Defeng Wen1, Pu Guo , Yu Liu , Zhongyuan Wu , Shulin Fu , Chun Ye , Xu Wang ,Yinsheng Qiu*. 18β-Glycyrrhetinic Acid Alleviates P. multocidaInduced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells. Infection and Drug Resistance 2023:16 4201–4212.(*corresponding author)

2.Lijuan Peng,Chun Peng,Shulin Fu,Yinsheng Qiu*.Adsorption-desorption and degradation of colistin in soils under aerobic conditions. Ecotoxicol Environ Saf. 2022 ,243:113989(*corresponding author)

3.Jianglin Xiong , Defeng Wen , Hualin Zhou , Rong Chen a , Hua Wang , Chong Wang , Zhongyuan Wu ,Yinsheng Qiu*, Lingying Wu*. Occurrence of aflatoxin M1 in yogurt and milk in central-eastern China and the risk of exposure in milk consumers. Food Control 2022;137:108928(*corresponding author)

4.Ling Guo,Hongxing Cheng,Shulin Fu,Jun Liu,Yunfei Zhang,Yinsheng Qiu*,Hongbo Chen.Methylome and Transcriptome-Based Integration Analysis Identified Molecular Signatures Associated With Meningitis Induced byGlaesserella parasuisFront Immunol. 2022;13:840399.(*corresponding author)

5. Shulin Fu , Yuzhen Yuan, Xinyue Tian, Linglu Zhou, Ling Guo, Dan Zhang, Jing He , Chun Peng ,Yinsheng Qiu*, Chun Ye, Yu Liu and Bingbing Zong. Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations. Vet. Sci. 2022, 9, 666.(*corresponding author)

6.Ling Guo,Dan Zhang,Shulin Fu,Jiacheng Zhang,Xiaofang Zhang,Jing He,Chun Peng,Yunfei Zhang,Yinsheng Qiu*,Chun Ye,Yu Liu,Zhongyuan Wu,Chien-An Andy Hu. Metagenomic Sequencing Analysis of the Effects of Colistin Sulfate on the Pig Gut Microbiome.Front Vet Sci. 2021;8:663820.(*corresponding author)

7.Shulin Fu,Qingyan Meng,Dan Zhang,Sanling Zuo,Jing He,Ling Guo,Yinsheng Qiu*,Chun Ye,Yulan Liu,Chien-An Andy Hu. Effect of Baicalin on Transcriptome Changes in Piglet Vascular Endothelial Cells Induced by a Combination of Glaesserella parasuis and Lipopolysaccharide. DNA CellBiol.2021;40(6):776-790.(*corresponding author)

8. Shulin Fu, Ronghua Yin, Sanling Zuo, Jun Liu, Yunfei Zhang, Ling Guo ,Yinsheng Qiu*, Chun Ye , Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An Andy Hu . The effects of baicalin on piglets challenged with Glaesserella parasuis. Vet Res. 2020;51(1):102. (*corresponding author)

9. Fu S, Liu J, Xu J, Zuo S, Zhang Y, Guo L,Qiu Y*, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis. Mol Cell Biochem. 2020;472(1-2):45-56. (*corresponding author)

10. Guo L, Liu J, Zhang Y, Fu S,Qiu Y, Ye C, Liu Y, Wu Z, Hou Y, Hu CA. The Effect of Baicalin on the Expression Profiles of Long Non-Coding RNAs and mRNAs in Porcine Aortic Vascular Endothelial Cells Infected with Haemophilus parasuis DNA Cell Biol. 2020;39(5):801-815

11. Yu Liu, Wenhua Zhao, Jianfeng Xu, Xiaolin Yu, Chun Ye, Shulin Fu,Yinsheng Qiu*. Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets. J vet Pharmacol Therap. 2019;42:580–584. (*corresponding author)

12. Shulin Fu, Wenhua Zhao, Chunhong Xiong, Ling Guo, Jing Guo,Yinsheng Qiu*, Chien-An Andy Hu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou. Baicalin modulates apoptosisviaRAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion. Innate Immunity.2019; 25(7):420-432.(*corresponding author)

13. Chun Ye, Ruizhi Li, Lei Xu,Yinsheng Qiu*, Shulin Fu, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An Andy Hu. Effects of Baicalin on piglet monocytes involving PKC–MAPK signaling pathways induced by Haemophilus parasuis. BMC Vet Res. 2019; 15(1):98.(*corresponding author)

14. Shulin Fu, Feng Zhuang, Ling Guo,Yinsheng Qiu*, Jianglin Xiong, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An Andy Hu.Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets. Int J Mol Sci. 2019; 20(10): 2390. (*corresponding author)

15. Xiong J, Zhu Q, Zhao Y, Yang S, Cao J,Qiu Y. Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. J Vet Pharmacol Ther. 2019;42(3):336-345

16. Xiong J, Sha H, Zhou H, Peng L, Wu L,Qiu Y, Wang R, Hu X. 2,4-Dinitrotoluene (DNT) Perturbs Yolk Absorption, Liver Development and Lipid Metabolism/Oxygen Transport Gene Expression in Zebrafish Embryos and Larvae. 2019;Int J Mol Sci. 2019;20(15):3632

17. Jincheng Xiong, Qianqian Zhu, Zhixin Le, Shuaike Yang, Peiyuan Chen, Yaxin Zhao, Jiyue Cao* andYinsheng Qiu*.Bioequivalence evaluation of two 5% ceftiofur hydrochloride sterile suspension in pigs. J Vet Med Sci. 2018; 80(12): 1847-1852. (*corresponding author)

18.Fu S,Liu H,Chen X,Qiu Y*,Ye C,Liu Y,Wu Z,Guo L,Hou Y,Hu CA. Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation.Int J Mol Sci.2018; 19:1307. (*corresponding author)

19.Fu S,Guo J,Li R,Qiu Y*,Ye C,Liu Y,Wu Z,Guo L,Hou Y,Hu CA. Transcriptional Profiling of Host Cell Responses to Virulent Haemophilus parasuis: New Insights into Pathogenesis.Int J Mol Sci.2018; 19:1320. (*corresponding author)

20.Fu S,Liu H,Xu L,Qiu Y*,Liu Y,Wu Z,Ye C,Hou Y,Hu CA. Baicalin modulates NF-κB and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glässer's disease.Sci Rep.2018; 8:807. (*corresponding author)

21.Lei Z,Liu Q,Yang S,Yang B,Khaliq H,Li K,Ahmed S,Sajid A,Zhang B,Chen P,Qiu Y*,Cao J*,He Q*. PK-PD Integration Modeling and Cutoff Value of Florfenicol against Streptococcus suis in Pigs.Front Pharmacol.2018; 9:2.(*corresponding author)

22. Guo L, Guo J, Liu H, Zhang J, Chen X,Qiu Y, Fu S.Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis. J Vet Med Sci. 2018; 80(7):1047-1053.

23.Yang B,Lei Z,Zhao Y,Ahmed S,Wang C,Zhang S,Fu S, Jiyue Cao*,Yinsheng Qiu*. Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation.Front Microbiol.2017; 8:2125.(*corresponding author)

24. Zhixin Lei , Shulin Fu, Bing Yang, Qianying Liu, Saeed Ahmed , Lei Xu , Jincheng Xiong, Jiyue Cao*,Yinsheng Qiu*. Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis.Sci Rep.2017; 7:7517.(*corresponding author)

25. Liu Y, Wang X, Hou Y, Yin Y,Qiu Y, Wu G, Hu CA. Roles of amino acids in preventing and treating intestinal diseases: recent studies with pig models. Amino Acids. 2017;49(8):1277-1291

26. Guo L, Xu L, Wu T, Fu S,Qiu Y, Hu CA, Ren X, Liu R, Ye M. Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model.Can J Microbiol. 2017;63(4):312-320

27. Shulin Fu, Lei Xu, Sali Li,Yinsheng Qiu*, Yu Liu, Zhongyuan Wu, Chun Ye, Yongqing Hou, Chien‑An Andy Hu. Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B(NF-κB) signaling during Haemophilus parasuis infection. Vet Res. 2016; 47:80. (*corresponding author)

28. Chun Ye, Sali Li, Wenxu Yao, Lei Xu,Yinsheng Qiu*, Yu Liu, Zhongyuan Wu, Yongqing Hou. The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes. Innate Immunity. 2016; 22(3): 196-204. (*corresponding author)

29. Yu Liu, WenxuYao, Jun Xu,Yinsheng Qiu*, Fangyuan Cao, Sali Li, Sheng Yang, Hailan Yang, Zhongyuan Wu, Yongqing Hou. The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of NLRP3 inflammasome pathway in lipopolysaccharide-challenged piglet mononuclear phagocytes. Innate Immunity. 2015; 21(6): 587-597. (*corresponding author)

30. Hu CA, Hou Y, Yi D,Qiu Y, Wu G, Kong X, Yin Y. Autophagy and tight junction proteins in the intestine and intestinal diseases. Anim Nutr. 2015;1(3):123-127.

31. Liu Yu; Yang Hailan; Yang Sheng; Hu Qiwei; Cheng Hongbo; Liu Huiyu;Qiu Yinsheng*. High-performance liquid chromatography using pressurized liquid extraction for the determination of seven tetracyclines in egg, fish and shrimp. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2013; 917: 11-17. (*corresponding author)

32.Qiu Y,Cao F, Xu J, Ma H, Zhang J, Liu Y. Effect of N-acetylcysteine on pharmacokinetics of acetaminophen in piglets. J Vet Pharmacol Ther. 2013; 36:507-510.

33.Qiu Y, Zhang J, Liu Y, Ma H, Cao F, Xu J, Hou Y, Xu L. The combination effects of acetaminophen and N–acetylcysteine on cytokines production and NF–κB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo. Vet Immunol Immunopathol. 2013; 152(3–4):381-388.

34. Hou Y, Wang L, Yi D, Ding B, Yang Z, Li J, Chen X,Qiu Y, Wu G. N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids. 2013;45(3):513-22.

35. Xu L,Qiu Y, Xu H, Ao W, Lam W, Yang X. Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents. Food Chem Toxicol. 2013;57:371-9.

36. Hou Y, Wang L, Zhang W, Yang Z, Ding B, Zhu H, Liu Y,Qiu Y, Yin Y, Wu G. Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide. Amino Acids. 2012;43(3):1233-42.

37. Wu T, Zhao Z, Zhang L, Ma H, Lu K, Ren W, Liu Z, Chang H, Bei W,Qiu Y, Chen H. Trigger factor of Streptococcus suis is involved in stress tolerance and virulence. Microb Pathog. 2011;51(1-2):69-76.

38. Xu L, Pan J, Chen Q, Yu Q, Chen H, Xu H,Qiu Y, Yang X. In vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsion. Food Chem Toxicol. 2008;46(12):3792-9.

39.尹荣华,熊春红,叶纯,邱银生*。兽用黄连解毒方剂UPLC指纹特征及三种成分含量测定。武汉轻工大学学报,2020,39(2):16-21(*通讯作者)

40.熊春红,赵文华,刘宇,付书林,邱银生*。黄芩苷对脂多糖诱导后仔猪血清和组织中炎性细胞因子表达的影响。黑龙江畜牧兽医,2020,3:110-115(*通讯作者)

42.庄锋,赵文华,付书林,刘宇,邱银生*。黄芩苷对脂多糖诱导后仔猪生理机能的影响。黑龙江畜牧兽医,2020,8:105-109(*通讯作者)

42.赵文华,庄锋,熊春红,刘宇,付书林,邱银生*。黄芩苷对脂多糖诱导后仔猪的血管紧密连接蛋白表达量和MLCK-MLC的影响。中国畜牧兽,2019,11:3190-3197(*通讯作者)

43.徐健峰,郭靖,刘华山,付书林,邱银生*。黄芩苷对副猪嗜血杆菌诱导后猪血管内皮细胞黏附分子表达的影响。武汉轻工大学学报,2019,38(1):17-21(*通讯作者)

44.杨海兰,姚文旭,李洒丽,武慧芳,杨胜,吴仲元,刘宇,邱银生*.帕托珠利和妥曲珠利在肉鸡体内残留消除的比较研究。黑龙江畜牧兽医,2015,2:229-232(*通讯作者)

45.杨胜,徐俊,杨海兰,邱银生*.乙酰半胱氨酸对阿莫西林和硫酸黏菌素抗菌作用的影响.黑龙江畜牧兽医,2014,17:161-163(*通讯作者)

46.徐俊,曹芳元,徐敏,祝圆,邱银生*.头孢噻呋钠在成年麻鸭体内的药代动力学研究.中国兽药杂志,2012,9:18-21(*通讯作者)

47.马振亮,杨海兰,张家威,徐俊,曹芳元,杨胜,邱银生*.对乙酰氨基酚联合乙酰半胱氨酸对脂多糖诱导仔猪抗氧化能力的影响.黑龙江畜牧兽医,2013,4:12-15(*通讯作者)

48.张家威,邱银生*,曹芳元,杨海兰,杨胜,马振亮,徐俊.对乙酰氨基酚联合乙酰半胱氨酸对仔猪免疫应激性炎症的影响.黑龙江畜牧兽医,2013,1:12-15(*通讯作者)

49.马红伟,吴涛,肖飞,高海鹏,邱银生*.阿莫西林和硫酸粘菌素对猪鸡大肠杆菌和沙门氏菌的体外联合抗菌作用.中国兽药杂志,2009,43(5):30-32

50.肖飞,马红伟,邱银生*.猪和鸡血浆中硫酸黏杆菌素浓度的高效液相色谱-荧光检测.中国兽医科学,2010,1:103-106(*通讯作者)

51.高海鹏,肖飞,马红伟,邱银生*.盐酸小檗碱包被颗粒的制备及溶出度研究.黑龙江畜牧兽医,2010,7:146-147(*通讯作者)

52.陶胜利,邱银生*,乐祥鹏,肖飞.混饮低剂量人和鸡α-干扰素对健康肉鸡免疫功能及生产性能的影响.黑龙江畜牧兽医,2009,10:36-38(*通讯作者)

53.邱银生,陈杖榴.近年来国外上市的兽用化学药物主要品种介绍.新兽医,2005,3:53~55

54.邱银生.国内外兽用化学药物研究进展与发展趋势.中国动物保健,2004,10:15~18

55.邱银生,袁宗辉,殷居易.猪食用组织中喹喔啉-2-羧酸的高液相色谱检测方法.中国兽医学报,2003,23(3):286~288

56.邱银生,袁宗辉,范盛先等.高效液相色谱法测定猪血浆及组织中喹赛多及其脱二氧代谢物.中国兽医学报,2003,23(4):363~365

57.邱银生,操继跃,王大菊等.盐酸沙拉沙星在肉鸡组织中的残留.中国兽医学报,2001,21(5):515~518

58.邱银生,王大菊,周祖坤等.氧阿苯达唑和阿苯达唑在绵羊体内代谢物的比较药物动力学.华中农业大学学报,2000,19(5):461~464

59.邱银生.兽用抗菌新药巴喹普林及其复方制剂.中国兽药杂志,2000;34(6):52~54

53.邱银生.抗生素后效应及其在兽医药物治疗中的意义.中国兽药杂志,2000;34(3):51~53

60.邱银生,周祖坤,潘经媛等.高效液相色谱法测定外用培氟沙星软膏后兔皮肤中药物浓度.数理医药学杂志,1999,12(2):152~153

61.邱银生,吴佳.动物专用氟喹诺酮类药物研究进展.中国兽药杂志,1998;32(3):46~48

62.邱银生,吴佳.兽用广谱抗菌药物氟甲砜霉素.中国兽药杂志,1996;30(2):47~48

63.邱银生.喹诺酮类药物在动物组织中的残留.中国兽药杂志,1996,30(1):46~49

64.邱银生,王大菊,郝玉萍等.烟酸诺氟沙星在猪、鸡体内的组织残留研究.中国兽药杂志,1994,28(3):10~12

65.邱银生.兽用喹诺酮类抗菌剂甲磺酸达诺沙星的研究慨况.中国兽药杂志,1994;28(1):51~53

66.邱银生,朱式欧,江美安等.甲磺酸培氟沙星在犬体内的药物动力学及片剂的生物利用度.中国医药工业杂志,1994,25(12):546~549

67.邱银生,李涛.丙硫苯咪唑在兔组织内的代谢动力学.东北农业大学学报,1993,24(1):48~53

68.邱银生.兽用喹诺酮类抗菌剂恩诺沙星的研究慨况.中国兽药杂志,1993,27(3):49~51

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